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| http://purl.uniprot.org/citations/23624913 | http://www.w3.org/2000/01/rdf-schema#comment | "Substrate-specific degradation is a key feature of the ubiquitin proteasome system. Substrate specificity is typically directed by the E3 or ubiquitin ligase; such specificity can be conferred either by ligase modification or expression or conversely via modification of substrates that permit their recognition by a specific E3 ligase. The most well-known example of such complexes are the Cullin-RING ligases (CRLs). CRLs are composed of one of seven cullin-family scaffold proteins; the CRL serves as a scaffold that interacts directly with a RING-domain enzyme (Rbx1/2) through an extensive protein-protein interface within the globular C-terminal domain. At the N terminus, the cullin associates with an adaptor protein through cullin-repeat motifs. This adaptor, in turn, facilitates recruitment of a substrate-specifying factor that recruits the target to be ubiquitylated. The prototypical CRL is the cul1-containing complex, commonly referred to as the Skp1-Cul1-Fbox (SCF) ligase. SCF ligases contribute to the timely destruction of numerous substrates thereby ensuring normal cell growth. The importance of SCF function is highlighted by cancer-specific alterations in either the expression or the function of select F-box substrate-specific adaptors that results in neoplastic conversion. Herein, we discuss the current understanding of SCF function and contribution to cell biology."xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.144"xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/author | "Lee E.K."xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/author | "Diehl J.A."xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/pages | "2011-2018"xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/title | "SCFs in the new millennium."xsd:string |
| http://purl.uniprot.org/citations/23624913 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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