| http://purl.uniprot.org/citations/23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23624922 | http://www.w3.org/2000/01/rdf-schema#comment | "SPROUTY2 (SPRY2) is an intracellular regulator of receptor tyrosine kinase signaling involved in cell growth, differentiation and tumorigenesis. Here, we show that SPRY2 is a target gene of the Wnt/β-catenin pathway that is abnormally activated in more than 90% of colon carcinomas. In human colon cancer cells, SPRY2 expression is induced by β-catenin in co-operation with the transcription factor FOXO3a instead of lymphoid enhancer factor/T-cell factor proteins. We found binding of β-catenin to the SPRY2 promoter at FOXO3a response elements. In vivo, cells marked by nuclear β-catenin and FOXO3a express SPRY2 in proliferative epithelial tissues, such as intestinal mucosa and epidermis. Consistently, inducible β-catenin deletion in mice reduced Spry2 expression in the small intestine. Moreover, SPRY2 protein expression correlated with nuclear β-catenin and FOXO3a colocalization in human colon carcinomas. Importantly, the amount of SPRY2 protein correlated with shorter overall survival of colon cancer patients. Our data reveal SPRY2 as a novel Wnt/β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.140"xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Munoz A."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Huelsken J."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Tenbaum S."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Irmisch A."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Barbachano A."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Palmer H.G."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Landolfi S."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Ordonez-Moran P."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Tabernero J."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/author | "Chicote I."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/pages | "1975-1985"xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/title | "SPROUTY2 is a beta-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer."xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23624922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23624922 |
| http://purl.uniprot.org/citations/23624922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23624922 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624922 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624922 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624922 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624922 |
| http://purl.uniprot.org/uniprot/#_A0A856PRE8-mappedCitation-23624922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23624922 |