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http://purl.uniprot.org/citations/23627023http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23627023http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore whether the membrane-associated protein Flotillin-1 has relationship with endocytosis of PrPc.

Methods

The expression of Flotillin-1 in different cell lines was detected with the method of Western Blot; the interaction between Flotillin-1 and PrPc in Cells which were treated with copper ions was observed using immunoprecipitation method.

Results

(1) Flotillin-1 was widely expressed in many cell lines without significant difference in the amounts of expression level; (2) Only in the appearance of copper ions, the protein complexes of PrPc and Flotillin-1 can be detected with the method of IP, which were related to copper ions concentration and processing time.

Conclusion

The membrane-associated protein Flotillin-1 has the relationship with the endocytosis of PrPc."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Gao C."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Xu Y."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Wang K."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Dong X.P."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Ren K."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Li L.Z."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/author"Yan Y.E."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/name"Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/pages"435-438"xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/title"[Study on the correlation between membrane protein Flotillin-1 and PrPc endocytosis]."xsd:string
http://purl.uniprot.org/citations/23627023http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/23627023http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23627023
http://purl.uniprot.org/citations/23627023http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23627023
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http://purl.uniprot.org/uniprot/#_B3KQX7-mappedCitation-23627023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23627023
http://purl.uniprot.org/uniprot/#_B4DDS1-mappedCitation-23627023http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23627023
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