| http://purl.uniprot.org/citations/23629809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23629809 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent murine studies have demonstrated that tumor-associated macrophages in the tumor microenvironment are a key source of the pro-tumorigenic cysteine protease, cathepsin S. We now show in a syngeneic colorectal carcinoma murine model that both tumor and tumor-associated cells contribute cathepsin S to promote neovascularization and tumor growth. Cathepsin S depleted and control colorectal MC38 tumor cell lines were propagated in both wild type C57Bl/6 and cathepsin S null mice to provide stratified depletion of the protease from either the tumor, tumor-associated host cells, or both. Parallel analysis of these conditions showed that deletion of cathepsin S inhibited tumor growth and development, and revealed a clear contribution of both tumor and tumor-associated cell derived cathepsin S. The most significant impact on tumor development was obtained when the protease was depleted from both sources. Further characterization revealed that the loss of cathepsin S led to impaired tumor vascularization, which was complemented by a reduction in proliferation and increased apoptosis, consistent with reduced tumor growth. Analysis of cell types showed that in addition to the tumor cells, tumor-associated macrophages and endothelial cells can produce cathepsin S within the microenvironment. Taken together, these findings clearly highlight a manner by which tumor-associated cells can positively contribute to developing tumors and highlight cathepsin S as a therapeutic target in cancer."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.28238"xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Walker B."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Burrows J.F."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Jaworski J."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Kissenpfennig A."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Spence S."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Burden R.E."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "McFarlane C."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Scott C.J."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Small D.M."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "McCarthy H.O."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/author | "Hegarty S.M."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/pages | "2102-2112"xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/title | "Cathepsin S from both tumor and tumor-associated cells promote cancer growth and neovascularization."xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://purl.uniprot.org/core/volume | "133"xsd:string |
| http://purl.uniprot.org/citations/23629809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23629809 |
| http://purl.uniprot.org/citations/23629809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23629809 |
| http://purl.uniprot.org/uniprot/#_F6WR04-mappedCitation-23629809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629809 |
| http://purl.uniprot.org/uniprot/#_Q8BSZ5-mappedCitation-23629809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629809 |
| http://purl.uniprot.org/uniprot/#_Q99M14-mappedCitation-23629809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629809 |