| http://purl.uniprot.org/citations/23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23629864 | http://www.w3.org/2000/01/rdf-schema#comment | "The costimulatory receptor Slamf6 partially controls lupus-related autoimmunity in congenic Sle1b mice; for instance, the presence of the protein isoform Slamf6-H1 in Sle1b.Slamf6-H1 mice mitigates disease. Here, we report that young Sle1b mice, but not Sle1b.Slamf6-H1 or B6 mice, contain a memory T-helper cell subset identified by ]mt]2-fold increase in expression of 17 genes, chief among which is Spp1, encoding the cytokine osteopontin (OPN). These T follicular helper (TFH) cells, including OPN(+) TFH cells, expand concomitantly with severity of the disease. By contrast, Sle1b.Slamf6-H1 or Sle1b.SAP(-)/(-) mice do not develop autoantibodies and the number of T(FH) cells is 5 times lower than in age-matched Sle1b mice. By comparing Sle1b and Sle1b.OPN(-)/(-) mice, we find that the lack of OPN expression impedes early autoantibody production. Furthermore, on the adoptive transfer of Sle1b.OPN(-)/(-) CD4(+) T cells into bm12 recipients autoantibody production and germinal center formation is reduced compared to recipients of Sle1b.OPN(+/+) CD4(+) T cells. We propose a model in which OPN provides a survival signal for a precursor T(FH) cell subset, which is a key factor in autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.12-226951"xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Tsokos G.C."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Wang N."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Detre C."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "O'Keeffe M."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Terhorst C."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Castro W."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Keszei M."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Kis-Toth K."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/author | "Magelky E."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/pages | "3123-3131"xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/title | "Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor."xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23629864 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23629864 |
| http://purl.uniprot.org/citations/23629864 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23629864 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY21-mappedCitation-23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629864 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629864 |
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| http://purl.uniprot.org/uniprot/#_A0A494B9G5-mappedCitation-23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629864 |
| http://purl.uniprot.org/uniprot/#_A0A494B9U2-mappedCitation-23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629864 |
| http://purl.uniprot.org/uniprot/#_B2RWI0-mappedCitation-23629864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23629864 |