| http://purl.uniprot.org/citations/23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23630078 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are critical to proliferation, differentiation, and development. Here, we characterize gene expression in murine Dicer-null adult mesenchymal stem cell lines, a fibroblast cell type. Loss of Dicer leads to derepression of let-7 targets at levels that exceed 10-fold to 100-fold with increases in transcription. Direct and indirect targets of this miRNA belong to a mid-gestation embryonic program that encompasses known oncofetal genes as well as oncogenes not previously associated with an embryonic state. Surprisingly, this mid-gestation program represents a distinct period that occurs between the pluripotent state of the inner cell mass at embryonic day 3.5 (E3.5) and the induction of let-7 upon differentiation at E10.5. Within this mid-gestation program, we characterize the let-7 target Nr6a1, an embryonic transcriptional repressor that regulates gene expression in adult fibroblasts following miRNA loss. In total, let-7 is required for the continual suppression of embryonic gene expression in adult cells, a mechanism that may underlie its tumor-suppressive function."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.215376.113"xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Sharp P.A."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Whittaker C.A."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Young R.A."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Rahl P.B."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Ravi A."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Gurtan A.M."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Bhutkar A."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "Bosson A.D."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/author | "JnBaptiste C.K."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/pages | "941-954"xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/title | "Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23630078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23630078 |
| http://purl.uniprot.org/citations/23630078 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23630078 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQG4-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |
| http://purl.uniprot.org/uniprot/#_E9Q9J9-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |
| http://purl.uniprot.org/uniprot/#_A0A0H3XWX3-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1A7-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |
| http://purl.uniprot.org/uniprot/#_D3YVQ2-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |
| http://purl.uniprot.org/uniprot/#_P52927-mappedCitation-23630078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630078 |