| http://purl.uniprot.org/citations/23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23630608 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the fact that mitochondrial dysfunction has an important role in tumorigenesis and metastasis, the underlying mechanism remains to be elucidated. Mitochondrial Complex I (NADH:ubiquinone oxidoreductase) is the first and the largest protein complex of the mitochondrial electron-transport chain (ETC),which has an essential role in maintaining mitochondrial function and integrity. In this study, we separately knocked down two subunits of mitochondrial complex I, GRIM-19 or NDUFS3, and investigated their effects on metastatic behaviors and explored the possible mechanisms. Our data showed that stable down-modulation of GRIM-19 or NDUFS3 decreased complex I activity and reactive oxygen species (ROS) production; led to enhanced cell adhesion, migration, invasion, and spheroid formation; and influenced the expressions of extracellular matrix (ECM) molecules and its related proteins. We also observed that the expressions of GRIM-19, NDUFS3, and ECM elements were correlated with invasive capabilities of breast cancer cell lines. These results suggest that inhibition of complex I affects metastatic properties of cancer cells, and mitochondrial ROS might play a crucial role in these processes by regulating ECM."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0061677"xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Lu H."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Zhao P."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Zhou A."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/author | "Yue X."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/pages | "e61677"xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/title | "Suppression of mitochondrial complex I influences cell metastatic properties."xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23630608 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23630608 |
| http://purl.uniprot.org/citations/23630608 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23630608 |
| http://purl.uniprot.org/uniprot/#_B4DEZ3-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/#_G3V194-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/#_O75489-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/#_Q53FM7-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/#_Q9UF24-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/#_Q9P0J0-mappedCitation-23630608 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23630608 |
| http://purl.uniprot.org/uniprot/G3V194 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23630608 |