| http://purl.uniprot.org/citations/23631755 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23631755 | http://www.w3.org/2000/01/rdf-schema#comment | "We characterized the mechanism and pharmacodynamics of five structurally distinct inhibitors of d-amino acid oxidase. All inhibitors bound the oxidized form of human enzyme with affinity slightly higher than that of benzoate (Kd ≈ 2-4 μM). Stopped-flow experiments showed that pyrrole-based inhibitors possessed high affinity (Kd ≈ 100-200 nM) and slow release kinetics (k < 0.01 s(-1)) in the presence of substrate, while inhibitors with pendent aromatic groups altered conformations of the active site lid, as evidenced by X-ray crystallography, and showed slower kinetics of association. Rigid bioisosteres of benzoic acid induced a closed-lid conformation, had slower release in the presence of substrate, and were more potent than benzoate. Steady-state d-serine concentrations were described in a PK/PD model, and competition for d-serine sites on NMDA receptors was demonstrated in vivo. DAAO inhibition increased the spatiotemporal influence of glial-derived d-serine, suggesting localized effects on neuronal circuits where DAAO can exert a neuromodulatory role."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.org/dc/terms/identifier | "doi:10.1021/jm4002583"xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Molla G."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Pollegioni L."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Hardy L.W."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Allen M.S."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Nardini M."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Melnick L."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Piubelli L."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Jones S.W."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Large T.H."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Koch P."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Oliet S.H."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Panatier A."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Varney M.A."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Bowen C.A."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Chytil M."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Fang Q.K."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Foglesong R.J."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Heffernan M.L."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Hopkins S.C."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Orsini M.A."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Saraswat L.D."xsd:string |
| http://purl.uniprot.org/citations/23631755 | http://purl.uniprot.org/core/author | "Soukri M."xsd:string |