| http://purl.uniprot.org/citations/23636126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23636126 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila Eyes Absent Homologue 1 (EYA1) is a component of the retinal determination gene network and serves as an H2AX phosphatase. The cyclin D1 gene encodes the regulatory subunits of a holoenzyme that phosphorylates and inactivates the pRb protein. Herein, comparison with normal breast showed that EYA1 is overexpressed with cyclin D1 in luminal B breast cancer subtype. EYA1 enhanced breast tumor growth in mice in vivo, requiring the phosphatase domain. EYA1 enhanced cellular proliferation, inhibited apoptosis, and induced contact-independent growth and cyclin D1 abundance. The induction of cellular proliferation and cyclin D1 abundance, but not apoptosis, was dependent upon the EYA1 phosphatase domain. The EYA1-mediated transcriptional induction of cyclin D1 occurred via the AP-1-binding site at -953 and required the EYA1 phosphatase function. The AP-1 mutation did not affect SIX1-dependent activation of cyclin D1. EYA1 was recruited in the context of local chromatin to the cyclin D1 AP-1 site. The EYA1 phosphatase function determined the recruitment of CBP, RNA polymerase II, and acetylation of H3K9 at the cyclin D1 gene AP-1 site regulatory region in the context of local chromatin. The EYA1 phosphatase regulates cell-cycle control via transcriptional complex formation at the cyclin D1 promoter."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-12-4078"xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Sun Y."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Wu K."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Chen K."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Cai S."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Tian L."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Pestell R.G."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/author | "Ertel A."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/pages | "4488-4499"xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/title | "EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1."xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/23636126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23636126 |
| http://purl.uniprot.org/citations/23636126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23636126 |
| http://purl.uniprot.org/uniprot/#_A0A2R8Y6K4-mappedCitation-23636126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23636126 |
| http://purl.uniprot.org/uniprot/#_B3KXR1-mappedCitation-23636126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23636126 |
| http://purl.uniprot.org/uniprot/#_A6NCB9-mappedCitation-23636126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23636126 |
| http://purl.uniprot.org/uniprot/#_F6YST4-mappedCitation-23636126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23636126 |