| http://purl.uniprot.org/citations/23637053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23637053 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy and up-regulation of autophagy-associated proteins microtubule-associated protein 1 light chain 3 (LC3) and Beclin-1 have been shown to occur in spinal cord injury (SCI). Bcl-2/E1B-19 K-interacting protein 3 (BNIP3) and Nip-like protein X (NIX, also known as BNIP3L) are mitochondrial BH3-only proteins that are implicated in mitophagy. In this study, we show that mitophagy is activated in the injured neurons, and hypoxia-inducible proteins BNIP3, NIX, and p53 are upregulated after SCI. Numerous autophagosomes containing damaged mitochondria (mitophagosomes) were found in the injured neurons 24 h after SCI in rats by transmission electron microscopy; mitophagy, therefore, had occurred. Hypoxia-inducible proteins BNIP3, NIX, and p53 were upregulated in spinal cord neurons in both a rat model of SCI and cultured primary spinal neurons exposed to hypoxia. BNIP3 and NIX were transcriptionally regulated mainly by hypoxia-inducible factor-1α as well as p53 in cultured spinal cord neurons. This study provides direct morphological and biochemical evidence for mitophagy in the damaged neural tissue after SCI."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12640-013-9397-0"xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/author | "Kong J."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/author | "Ni B."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/name | "Neurotox Res"xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/pages | "512-522"xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/title | "Induction of neuronal mitophagy in acute spinal cord injury in rats."xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23637053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23637053 |
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