| http://purl.uniprot.org/citations/23637227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23637227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23637227 | http://www.w3.org/2000/01/rdf-schema#comment | "Sphingosine 1-phosphate (S1P) is a bioactive lipid whose levels are tightly regulated by its synthesis and degradation. Intracellularly, S1P is dephosphorylated by the actions of two S1P-specific phosphatases, sphingosine-1-phosphate phosphatases 1 and 2. To identify the physiological functions of S1P phosphatase 1, we have studied mice with its gene, Sgpp1, deleted. Sgpp1(-/-) mice appeared normal at birth, but during the 1st week of life they exhibited stunted growth and suffered desquamation, with most dying before weaning. Both Sgpp1(-/-) pups and surviving adults exhibited multiple epidermal abnormalities. Interestingly, the epidermal permeability barrier developed normally during embryogenesis in Sgpp1(-/-) mice. Keratinocytes isolated from the skin of Sgpp1(-/-) pups had increased intracellular S1P levels and displayed a gene expression profile that indicated overexpression of genes associated with keratinocyte differentiation. The results reveal S1P metabolism as a regulator of keratinocyte differentiation and epidermal homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.478420"xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.478420"xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Proia R.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Allende M.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Allende M.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Tuymetova G."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Tuymetova G."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Sipe L.M."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Sipe L.M."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Wilson-Henjum K.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/author | "Wilson-Henjum K.L."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/pages | "18381-18391"xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/pages | "18381-18391"xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/title | "Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23637227 | http://purl.uniprot.org/core/title | "Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis."xsd:string |