| http://purl.uniprot.org/citations/23639442 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23639442 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis. We show that mice with a knockin mutation that ablates the NRP1 cytoplasmic tail (Nrp1(cyto)) have normal angiogenesis but impaired developmental and adult arteriogenesis. The arteriogenic defect was traced to the absence of a PDZ-dependent interaction between NRP1 and VEGF receptor 2 (VEGFR2) complex and synectin, which delayed trafficking of endocytosed VEGFR2 from Rab5+ to EAA1+ endosomes. This led to increased PTPN1 (PTP1b)-mediated dephosphorylation of VEGFR2 at Y(1175), the site involved in activating ERK signaling. The Nrp1(cyto) mutation also impaired endothelial tubulogenesis in vitro, which could be rescued by expressing full-length NRP1 or constitutively active ERK. These results demonstrate that the NRP1 cytoplasmic domain promotes VEGFR2 trafficking in a PDZ-dependent manner to regulate arteriogenic ERK signaling and establish a role for NRP1 in VEGF-A signaling during vascular morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.03.019"xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Zhuang Z."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Davis G."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Simons M."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Lanahan A."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Toomre D."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Ruhrberg C."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Rivera-Molina F."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Prahst C."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Fantin A."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/author | "Speichinger K."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/pages | "156-168"xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/title | "The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis."xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23639442 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23639442 |
| http://purl.uniprot.org/citations/23639442 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23639442 |
| http://purl.uniprot.org/uniprot/O14786#attribution-E9AC75B61474693EB03DAC49A98068DE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23639442 |
| http://purl.uniprot.org/uniprot/O14786#attribution-EA39B7412B9D00EF2A6A7574C62D76BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23639442 |