| http://purl.uniprot.org/citations/23642353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23642353 | http://www.w3.org/2000/01/rdf-schema#comment | "Dengue viruses (DENV), members of mosquito-borne Flaviviruses, are human pathogens of global significance. The virus enters the host cell through endocytosis and uncoating subsequent to a low pH-triggered conformational change of E protein in endosomes. The endosomes are active in antigen processing and the key enzyme involved is the gamma interferon-inducible lysosomal thiol reductase (GILT). Here, we sought to address the role of GILT in DENV2 entry using fibroblasts from wild type (WT) and GILT knockout (GILT(-/-)) mice (MFs) with defective antigen processing. Our results obtained using DENV2 infectious and Renilla luciferase reporter replicon RNAs show that WT MFs are relatively resistant and GILT(-/-) MFs are susceptible to DENV2 translation and replication. We show that DENV2 infection of WT MEFs induced autophagy based on an increased LC3-II/LC3-I ratio that is further enhanced in GILT(-/-) cells. The increased susceptibility of DENV2 infection in the GILT(-/-)MFs strongly correlates with increased autophagy."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2013.03.017"xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Teramoto T."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Padmanabhan R."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Manzano M."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Maric M."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Chiang H.S."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/author | "Takhampunya R."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/pages | "146-151"xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/title | "Gamma interferon-inducible lysosomal thioreductase (GILT) ablation renders mouse fibroblasts sensitive to dengue virus replication."xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://purl.uniprot.org/core/volume | "441"xsd:string |
| http://purl.uniprot.org/citations/23642353 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23642353 |
| http://purl.uniprot.org/citations/23642353 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23642353 |
| http://purl.uniprot.org/uniprot/#_Q9ESY9-mappedCitation-23642353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23642353 |
| http://purl.uniprot.org/uniprot/Q9ESY9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23642353 |