| http://purl.uniprot.org/citations/23643986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23643986 | http://www.w3.org/2000/01/rdf-schema#comment | "Several lines of evidence support that methamphetamine (METH) toxicity plays a pivotal role in neurodegenerative diseases. However, the molecular mechanisms underlying METH-induced neurotoxicity are still unclear. In addition, Ras modulated death signaling has been continually reported in several cell types. In this study, intracellular Ras-dependent death signaling cascade activation was proposed to contribute to METH-induced neuronal cell degeneration in dopaminergic SH-SY5Y cultured cells. Exposure to a toxic dose of METH significantly decreased cell viability, and tyrosine hydroxylase phosphorylation, but increased c-Jun phosphorylation and active, GTP-bound Ras in cultured SH-SY5Y cells. Farnesyltransferase inhibitor, FTI-277, an inhibitor of the enzyme catalyzed the farnesylation of Ras proteins was able to diminish the toxic effects of METH on induction in cell degeneration, activation in c-Jun-N-terminal kinase cascades, and Ras activation in SH-SY5Y cells. The results of this study show that activation in Ras signaling cascade may be implicated in the METH-induced death signaling pathway in neuroblastoma SH-SY5Y cells."xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neulet.2013.04.034"xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/author | "Govitrapong P."xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/author | "Chetsawang B."xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/author | "Pirompul N."xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/name | "Neurosci Lett"xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/pages | "138-143"xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/title | "Farnesyltransferase inhibitor attenuates methamphetamine toxicity-induced Ras proteins activation and cell death in neuroblastoma SH-SY5Y cells."xsd:string |
| http://purl.uniprot.org/citations/23643986 | http://purl.uniprot.org/core/volume | "545"xsd:string |
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