| http://purl.uniprot.org/citations/23645881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23645881 | http://www.w3.org/2000/01/rdf-schema#comment | "GARP/LRRC32 was defined as a marker of activated human regulatory T cells (Tregs) that is responsible for surface localization of latent TGF-β1. We find that GARP and latent TGF-β1 are also found on mouse Tregs activated via TCR stimulation; however, in contrast to human Tregs, GARP is also expressed at a low level on resting Tregs. The expression of GARP can be upregulated on mouse Tregs by IL-2 or IL-4 exposure in the absence of TCR signaling. GARP is expressed at a low level on Tregs within the thymus, and Treg precursors from the thymus concomitantly express GARP and Foxp3 upon exposure to IL-2. The expression of GARP is independent of TGF-β1 and TGF-β1 loading into GARP and is independent of furin-mediated processing of pro-TGF-β1 to latent TGF-β1. Specific deletion of GARP in CD4(+) T cells results in lack of expression of latent TGF-β1 on activated Tregs. GARP-deficient Tregs develop normally, are present in normal numbers in peripheral tissues, and are fully competent suppressors of the activation of conventional T cells in vitro. Activated Tregs expressing GARP/latent TGF-β1 complexes are potent inducers of Th17 differentiation in the presence of exogenous IL-6 and inducers of Treg in the presence of IL-2. Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-β1/GARP complex on their cell surface rather than by secreted latent TGF-β1."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300199"xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Fujii H."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Unutmaz D."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Shevach E.M."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Creemers J."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Edwards J.P."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/author | "Zhou A.X."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/pages | "5506-5515"xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/title | "Regulation of the expression of GARP/latent TGF-beta1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation."xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://purl.uniprot.org/core/volume | "190"xsd:string |
| http://purl.uniprot.org/citations/23645881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23645881 |
| http://purl.uniprot.org/citations/23645881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23645881 |
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