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http://purl.uniprot.org/citations/23652315http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23652315http://www.w3.org/2000/01/rdf-schema#comment"

Background

Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.

Methods

Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.

Results

Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).

Conclusion

Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.org/dc/terms/identifier"doi:10.1038/bjc.2013.215"xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Uhlen M."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Johannesson H."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Eberhard J."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Jirstrom K."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Nodin B."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Boman K."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Kuteeva E."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Malmstrom P.U."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Segersten U."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/author"Larsson A.H."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/name"Br J Cancer"xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/pages"2321-2328"xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/title"Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer."xsd:string
http://purl.uniprot.org/citations/23652315http://purl.uniprot.org/core/volume"108"xsd:string
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