| http://purl.uniprot.org/citations/23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23656597 | http://www.w3.org/2000/01/rdf-schema#comment | "Allergic asthma is a heterogeneous disease with no curative therapies. T cells infiltrate the airway smooth muscle (ASM) layer and may be implicated in airway remodeling and the increase of ASM mass, a cardinal feature of asthma. The mechanism by which CD4(+) T cells drive airway remodeling remains unknown. This study sought to determine the T cell-mediated mechanism of ASM cell proliferation. We hypothesized that CD4(+) T cells adhere to ASM cells via CD44, and induce ASM cell proliferation through the activation of the epidermal growth factor receptor (EGFR). A coculture model showed that the contact of antigen-stimulated CD4(+) T cells with ASM cells induced high levels of EGFR ligand expression in CD4(+) T cells and the activation of matrix metalloproteinase (MMP)-9, required for the shedding of EGFR ligands. The inhibition of EGFR and MMP-9 prevented the increase of ASM cell proliferation after coculture. The hyaluronan receptor CD44 is the dominant mediator of the tight adherence of T cells to ASM and is colocalized with MMP-9 on the cell surface. Moreover, the neutralization of CD44 prevents ASM cell hyperplasia. These data provide a novel mechanism by which antigen-stimulated CD4(+) T cells induce the remodeling indicative of a direct trophic role for CD4(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2012-0356oc"xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Tsuchiya K."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Laporte S.A."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Siddiqui S."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Martin J.G."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Al Heialy S."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Risse P.A."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Zeroual M.A."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/author | "Roman H.N."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/pages | "563-570"xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/title | "T cell-induced airway smooth muscle cell proliferation via the epidermal growth factor receptor."xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23656597 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23656597 |
| http://purl.uniprot.org/citations/23656597 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23656597 |
| http://purl.uniprot.org/uniprot/#_A8IP97-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_A6JPX8-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_A6JPX9-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_E7CXR8-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_E7CXR9-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_Q9JLR6-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |
| http://purl.uniprot.org/uniprot/#_Q62954-mappedCitation-23656597 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23656597 |