| http://purl.uniprot.org/citations/23658195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23658195 | http://www.w3.org/2000/01/rdf-schema#comment | "Mislocalization of axonal proteins can result in misassembly and/or miswiring of neural circuits, causing disease. To date, only a handful of genes that control polarized localization of axonal membrane proteins have been identified. Here we report that Drosophila X11/Mint proteins are required for targeting several proteins, including human amyloid precursor protein (APP) and Drosophila APP-like protein (APPL), to axonal membranes and for their exclusion from dendrites of the mushroom body in Drosophila, a brain structure involved in learning and memory. Axonal localization of APP is mediated by an endocytic motif, and loss of X11/Mint results in a dramatic increase in cell-surface levels of APPL, especially on dendrites. Mutations in genes required for endocytosis show similar mislocalization of these proteins to dendrites, and strongly enhance defects seen in X11/Mint mutants. These results suggest that X11/Mint-dependent endocytosis in dendrites may serve to promote the axonal localization of membrane proteins. Since X11/Mint binds to APP, and abnormal trafficking of APP contributes to Alzheimer's disease, deregulation of X11/Mint may be important for Alzheimer's disease pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5749-12.2013"xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/author | "Guo M."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/author | "Gross G.G."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/author | "Leung L.K."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/author | "Hartenstein V."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/author | "Lone G.M."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/pages | "8575-8586"xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/title | "X11/Mint genes control polarized localization of axonal membrane proteins in vivo."xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23658195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23658195 |
| http://purl.uniprot.org/citations/23658195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23658195 |
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