| http://purl.uniprot.org/citations/23658528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23658528 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23658528 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuropeptides play crucial roles in modulating neuronal networks, including changing intrinsic properties of neurons and synaptic efficacy. We previously reported a Caenorhabditis elegans mutant, acr-2(gf), that displays spontaneous convulsions as the result of a gain-of-function mutation in a neuronal nicotinic acetylcholine receptor subunit. The ACR-2 channel is expressed in the cholinergic motor neurons, and acr-2(gf) causes cholinergic overexcitation accompanied by reduced GABAergic inhibition in the locomotor circuit. Here we show that neuropeptides play a homeostatic role that compensates for this excitation-inhibition imbalance in the locomotor circuit. Loss of function in genes required for neuropeptide processing or release of dense core vesicles specifically modulate the convulsion frequency of acr-2(gf). The proprotein convertase EGL-3 is required in the cholinergic motor neurons to restrain convulsions. Electrophysiological recordings of neuromuscular junctions show that loss of egl-3 in acr-2(gf) causes a further reduction of GABAergic inhibition. We identify two neuropeptide encoding genes, flp-1 and flp-18, that together counteract the excitation-inhibition imbalance in acr-2(gf) mutants. We further find that acr-2(gf) causes an increased expression of flp-18 in the ventral cord cholinergic motor neurons and that overexpression of flp-18 reduces the convulsion of acr-2(gf) mutants. The effects of these peptides are in part mediated by two G-protein coupled receptors, NPR-1 and NPR-5. Our data suggest that the chronic overexcitation of the cholinergic motor neurons imposed by acr-2(gf) leads to an increased production of FMRFamide neuropeptides, which act to decrease the activity level of the locomotor circuit, thereby homeostatically modulating the excitation and inhibition imbalance."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003472"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1003472"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Zhou K."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Zhou K."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Stawicki T.M."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Stawicki T.M."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Takayanagi-Kiya S."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/author | "Takayanagi-Kiya S."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/pages | "E1003472"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/pages | "E1003472"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/title | "Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/title | "Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/23658528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23658528 |
| http://purl.uniprot.org/citations/23658528 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23658528 |