| http://purl.uniprot.org/citations/23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23661552 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF1 tumor suppressor protein neurofibromin is a negative regulator of Ras. Neurofibromin is dynamically regulated by the proteasome, and its degradation and reexpression are essential for maintaining appropriate levels of Ras-GTP. Like p53, NF1/neurofibromin can be inactivated in cancer by both mutations and excessive proteasomal destruction; however, little is known about the mechanisms that underlie this latter process. Here, we show that a Cullin 3 (Cul3)/kelch repeat and BTB domain-containing 7 complex controls both the regulated proteasomal degradation of neurofibromin and the pathogenic destabilization of neurofibromin in glioblastomas. Importantly, RNAi-mediated Cul3 ablation and a dominant-negative Cul3 directly stabilize neurofibromin, suppress Ras and extracellular signal-regulated kinase, and inhibit proliferation in an NF1-dependent manner. Moreover, in glioblastomas where neurofibromin is chronically destabilized, Cul3 inhibition restabilizes the protein and suppresses tumor development. Collectively, these studies show a previously unrecognized role for Cul3 in regulating Ras and provide a molecular framework that can be exploited to develop potential cancer therapies."xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.org/dc/terms/identifier | "doi:10.1158/2159-8290.cd-13-0146"xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/author | "Hollstein P.E."xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/author | "Cichowski K."xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/name | "Cancer Discov"xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/pages | "880-893"xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/title | "Identifying the Ubiquitin Ligase complex that regulates the NF1 tumor suppressor and Ras."xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23661552 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23661552 |
| http://purl.uniprot.org/citations/23661552 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23661552 |
| http://purl.uniprot.org/uniprot/#_Q15008-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_A5LHX3-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_O43242-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_P40306-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_P0CG47-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_P0CG48-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_Q13200-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_Q14997-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_O00231-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_O00232-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_O00233-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_P28062-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |
| http://purl.uniprot.org/uniprot/#_P28065-mappedCitation-23661552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23661552 |