| http://purl.uniprot.org/citations/23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23663783 | http://www.w3.org/2000/01/rdf-schema#comment | "RNAP II is frequently paused near gene promoters in mammals, and its transition to productive elongation requires active recruitment of P-TEFb, a cyclin-dependent kinase for RNAP II and other key transcription elongation factors. A fraction of P-TEFb is sequestered in an inhibitory complex containing the 7SK noncoding RNA, but it has been unclear how P-TEFb is switched from the 7SK complex to RNAP II during transcription activation. We report that SRSF2 (also known as SC35, an SR-splicing factor) is part of the 7SK complex assembled at gene promoters and plays a direct role in transcription pause release. We demonstrate RNA-dependent, coordinated release of SRSF2 and P-TEFb from the 7SK complex and transcription activation via SRSF2 binding to promoter-associated nascent RNA. These findings reveal an unanticipated SR protein function, a role for promoter-proximal nascent RNA in gene activation, and an analogous mechanism to HIV Tat/TAR for activating cellular genes."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.028"xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Lin C.Y."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Xiao R."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Ji X."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Pandit S."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Fu X.D."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/author | "Burge C.B."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/pages | "855-868"xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/title | "SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase."xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://purl.uniprot.org/core/volume | "153"xsd:string |
| http://purl.uniprot.org/citations/23663783 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23663783 |
| http://purl.uniprot.org/citations/23663783 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23663783 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0V5-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |
| http://purl.uniprot.org/uniprot/#_B0R021-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |
| http://purl.uniprot.org/uniprot/#_D6RGN3-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |
| http://purl.uniprot.org/uniprot/#_D6RHP4-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |
| http://purl.uniprot.org/uniprot/#_H3BJA4-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |
| http://purl.uniprot.org/uniprot/#_F6QXN3-mappedCitation-23663783 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23663783 |