| http://purl.uniprot.org/citations/23663784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23663784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23663784 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor-α (TNF-α) is the most potent proinflammatory cytokine in mammals. The degradation of TNF-α mRNA is critical for restricting TNF-α synthesis and involves a constitutive decay element (CDE) in the 3' UTR of the mRNA. Here, we demonstrate that the CDE folds into an RNA stem-loop motif that is specifically recognized by Roquin and Roquin2. Binding of Roquin initiates degradation of TNF-α mRNA and limits TNF-α production in macrophages. Roquin proteins promote mRNA degradation by recruiting the Ccr4-Caf1-Not deadenylase complex. CDE sequences are highly conserved and are found in more than 50 vertebrate mRNAs, many of which encode regulators of development and inflammation. In macrophages, CDE-containing mRNAs were identified as the primary targets of Roquin on a transcriptome-wide scale. Thus, Roquin proteins act broadly as mediators of mRNA deadenylation by recognizing a conserved class of stem-loop RNA degradation motifs."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.016"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.016"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Stoecklin G."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Hammond M.C."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Hammond M.C."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Schott J."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Schott J."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Poetz F."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Poetz F."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Leppek K."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Leppek K."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Reitter S."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/author | "Reitter S."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/pages | "869-881"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/pages | "869-881"xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/title | "Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs."xsd:string |
| http://purl.uniprot.org/citations/23663784 | http://purl.uniprot.org/core/title | "Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs."xsd:string |