| http://purl.uniprot.org/citations/23664615 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23664615 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of neuronal excitability and cardiac excitation-contraction coupling requires the proper localization of L-type Ca²⁺ channels. We show that the actin-binding protein α-actinin binds to the C-terminal surface targeting motif of α11.2, the central pore-forming Ca(V)1.2 subunit, in order to foster its surface expression. Disruption of α-actinin function by dominant-negative or small hairpin RNA constructs reduces Ca(V)1.2 surface localization in human embryonic kidney 293 and neuronal cultures and dendritic spine localization in neurons. We demonstrate that calmodulin displaces α-actinin from their shared binding site on α11.2 upon Ca²⁺ influx through L-type channels, but not through NMDAR, thereby triggering loss of Ca(V)1.2 from spines. Coexpression of a Ca²⁺-binding-deficient calmodulin mutant does not affect basal Ca(V)1.2 surface expression but inhibits its internalization upon Ca²⁺ influx. We conclude that α-actinin stabilizes Ca(V)1.2 at the plasma membrane and that its displacement by Ca²⁺-calmodulin triggers Ca²⁺-induced endocytosis of Ca(V)1.2, thus providing an important negative feedback mechanism for Ca²⁺ influx."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2013.02.032"xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Lee A."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Hell J.W."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Nguyen M."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Tsuruta F."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Hall D.D."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Weinberg R.J."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Burette A."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Dolmetsch R.E."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Tseng P.Y."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Mohapatra D.P."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Matt L."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Schnizler K."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Malik Z."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Christel C.J."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/author | "Shephard A."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/pages | "483-497"xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/title | "Competition between alpha-actinin and Ca^2⁺-calmodulin controls surface retention of the L-type Ca^2⁺ channel Ca(V)1.2."xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/23664615 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23664615 |