| http://purl.uniprot.org/citations/23664973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23664973 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23664973 | http://www.w3.org/2000/01/rdf-schema#comment | "Survival requires that living organisms continuously monitor environmental and tissue pH. Animals sense acidic pH using ion channels and G-protein-coupled receptors (GPCRs), but monitoring of alkaline pH is not well understood. We report here that in the nematode Caenorhabditis elegans, a transmembrane receptor-type guanylyl cyclase (RGC), GCY-14, of the ASEL gustatory neuron, plays an essential role in the sensing of extracellular alkalinity. Activation of GCY-14 opens a cGMP-gated cation channel encoded by tax-2 and tax-4, resulting in Ca(2+) entry into ASEL. Ectopic expression of GCY-14 in other neurons indicates that it accounts for the alkalinity sensing capability. Domain-swapping and site-directed mutagenesis of GCY-14 reveal that GCY-14 functions as a homodimer, in which histidine of the extracellular domains plays a crucial role in alkalinity detection. These results argue that in addition to ion channels and GPCRs, RGCs also play a role in pH sensation in neurons."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2013.04.052"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cub.2013.04.052"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Fujiwara M."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Fujiwara M."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Maruyama I.N."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Maruyama I.N."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Murayama T."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Murayama T."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Takayama J."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/author | "Takayama J."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/pages | "1007-1012"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/pages | "1007-1012"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/title | "Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/title | "Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23664973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23664973 |
| http://purl.uniprot.org/citations/23664973 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23664973 |