| http://purl.uniprot.org/citations/23665919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23665919 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23665919 | http://www.w3.org/2000/01/rdf-schema#comment | "A neuronal F-box protein FSN-1 regulates Caenorhabditis elegans neuromuscular junction development by negatively regulating DLK-mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN-1-dependent synaptic development and function. The aberrant synapse morphology and synaptic transmission in fsn-1 mutants are partially and specifically rescued by reducing insulin/IGF-signalling activity in postsynaptic muscles, as well as by reducing the activity of EGL-3, a prohormone convertase that processes agonistic insulin/IGF ligands INS-4 and INS-6, in neurons. FSN-1 interacts with, and potentiates the ubiquitination of EGL-3 in vitro, and reduces the EGL-3 level in vivo. We propose that FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.91"xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2013.91"xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Gao S."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Hwang C."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Hwang C."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Chitturi J."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Zhen M."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Bessereau J.L."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Bessereau J.L."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Stigloher C."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Stigloher C."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Liao E.H."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Liao E.H."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Hung W.L."xsd:string |
| http://purl.uniprot.org/citations/23665919 | http://purl.uniprot.org/core/author | "Hung W.L."xsd:string |