| http://purl.uniprot.org/citations/23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23666637 | http://www.w3.org/2000/01/rdf-schema#comment | "Mesenchymal stem cells (MSCs) transplanted into injured myocardium promote repair through paracrine mechanisms. We have previously shown that MSCs over-expressing AKT1 (Akt-MSCs) exhibit enhanced properties for cardiac repair. In this study, we investigated the relevance of Abi3bp toward MSC biology. Abi3bp formed extracellular deposits with expression controlled by Akt1 and ubiquitin-mediated degradation. Abi3bp knockdown/knockout stabilized focal adhesions and promoted stress-fiber formation. Furthermore, MSCs from Abi3bp knockout mice displayed severe deficiencies in osteogenic and adipogenic differentiation. Knockout or stable knockdown of Abi3bp increased MSC and Akt-MSC proliferation, promoting S-phase entry via cyclin-d1, ERK1/2, and Src. Upon Abi3bp binding to integrin-β1 Src associated with paxillin which inhibited proliferation. In vivo, Abi3bp knockout increased MSC number and proliferation in bone marrow, lung, and liver. In summary, we have identified a novel extracellular matrix protein necessary for the switch from proliferation to differentiation in MSCs."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.org/dc/terms/identifier | "doi:10.1002/stem.1416"xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Dzau V.J."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Pratt R.E."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Hodgkinson C.P."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Davis B."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Gomez J.A."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Mirotsou M."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Schmeckpeper J."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Naidoo V."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/author | "Patti K.G."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/name | "Stem Cells"xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/pages | "1669-1682"xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/title | "Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology."xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/23666637 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23666637 |
| http://purl.uniprot.org/citations/23666637 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23666637 |
| http://purl.uniprot.org/uniprot/#_A0A338P6S8-mappedCitation-23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23666637 |
| http://purl.uniprot.org/uniprot/#_A0A338P6W9-mappedCitation-23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23666637 |
| http://purl.uniprot.org/uniprot/#_B2RWZ0-mappedCitation-23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23666637 |
| http://purl.uniprot.org/uniprot/#_E9Q8E3-mappedCitation-23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23666637 |
| http://purl.uniprot.org/uniprot/#_Q8BKQ1-mappedCitation-23666637 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23666637 |