| http://purl.uniprot.org/citations/23667053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23667053 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia is a prominent feature in the maintenance of hematopoietic stem cell (HSC) quiescence and multipotency. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain proteins (PHDs) serve as oxygen sensors and may therefore regulate this system. Here, we describe a mouse line with conditional loss of HIF prolyl hydroxylase 2 (PHD2) in very early hematopoietic precursors that results in self-renewal of multipotent progenitors under steady-state conditions in a HIF1α- and SMAD7-dependent manner. Competitive bone marrow (BM) transplantations show decreased peripheral and central chimerism of PHD2-deficient cells but not of the most primitive progenitors. Conversely, in whole BM transfer, PHD2-deficient HSCs replenish the entire hematopoietic system and display an enhanced self-renewal capacity reliant on HIF1α. Taken together, our results demonstrate that loss of PHD2 controls the maintenance of the HSC compartment under physiological conditions and causes the outcompetition of PHD2-deficient hematopoietic cells by their wild-type counterparts during stress while promoting the self-renewal of very early hematopoietic progenitors."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-12-471185"xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Stewart A.F."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Singh R.P."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Chavakis T."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Anastassiadis K."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Breier G."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Bornstein S."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Willam C."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Waskow C."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Kalucka J."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Franke K."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Naumann R."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Wielockx B."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Gembarska A."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Muschter A."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Grinenko T."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/author | "Mamlouk S."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/pages | "5158-5166"xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/title | "HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress."xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://purl.uniprot.org/core/volume | "121"xsd:string |
| http://purl.uniprot.org/citations/23667053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23667053 |