| http://purl.uniprot.org/citations/23667177 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23667177 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipoprotein oxidation plays an important role in pathogenesis of atherosclerosis. Oxidized low density lipoprotein (OxLDL) induces profound inflammatory responses in vascular cells, such as production of monocyte chemoattractant protein-1 (MCP-1) [chemokine (C-C motif) ligand 2], a key chemokine in the initiation and progression of vascular inflammation. Here we demonstrate that OxLDL also binds MCP-1 and that the OxLDL-bound MCP-1 retains its ability to recruit monocytes. A human MCP-1 mutant in which basic amino acids Arg-18 and Lys-19 were replaced with Ala did not bind to OxLDL. The MCP-1 binding to OxLDL was inhibited by the monoclonal antibody E06, which binds oxidized phospholipids (OxPLs) in OxLDL. Because OxPLs are carried by lipoprotein(a) [Lp(a)] in human plasma, we tested to determine whether Lp(a) binds MCP-1. Recombinant wild-type but not mutant MCP-1 added to human plasma bound to Lp(a), and its binding was inhibited by E06. Lp(a) captured from human plasma contained MCP-1 and the Lp(a)-associated endogenous MCP-1 induced monocyte migration. These results demonstrate that OxLDL and Lp(a) bind MCP-1 in vitro and in vivo and that OxPLs are major determinants of the MCP-1 binding. The association of MCP-1 with OxLDL and Lp(a) may play a role in modulating monocyte trafficking during atherogenesis."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.org/dc/terms/identifier | "doi:10.1194/jlr.m036343"xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Almazan F."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Choi S.H."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Witztum J.L."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Miller Y.I."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Wiesner P."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Handel T.M."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Iqbal N."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Chowdhury P."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Tsimikas S."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Maisel A."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Byun Y.S."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Chittka D."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/author | "Tafelmeier M."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/name | "J Lipid Res"xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/pages | "1877-1883"xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/title | "MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma."xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://purl.uniprot.org/core/volume | "54"xsd:string |
| http://purl.uniprot.org/citations/23667177 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23667177 |
| http://purl.uniprot.org/citations/23667177 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23667177 |