| http://purl.uniprot.org/citations/23669073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23669073 | http://www.w3.org/2000/01/rdf-schema#comment | "Development, growth and adult survival are coordinated with available metabolic resources, ascertaining that the organism responds appropriately to environmental conditions. MicroRNAs are short (21-23 nt) regulatory RNAs that confer specificity on the RNA-induced silencing complex (RISC) to inhibit a given set of mRNA targets. We profiled changes in miRNA expression during adult life in Drosophila melanogaster and determined that miR-277 is downregulated during adult life. Molecular analysis revealed that this miRNA controls branched-chain amino acid (BCAA) catabolism and as a result it can modulate the activity of the TOR kinase, a central growth regulator, in cultured cells. Metabolite analysis in cultured cells as well as flies suggests that the mechanistic basis may be an accumulation of branched-chain α-keto-acids (BCKA), rather than BCAAs, thus avoiding potentially detrimental consequences of increased branched chain amino acid levels on e.g., translational fidelity. Constitutive miR-277 expression shortens lifespan and is synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype. Transgenic inhibition with a miRNA sponge construct also shortens lifespan, in particular on protein-rich food. Thus, optimal metabolic adaptation appears to require tuning of cellular BCAA catabolism by miR-277."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.org/dc/terms/identifier | "doi:10.4161/rna.24810"xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Martin D."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Witte H."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Tresch A."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Cramer P."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Maier K.C."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Michalke B."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Forstemann K."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Helfer S."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Schwalb B."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Michalik K.M."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/author | "Esslinger S.M."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/name | "RNA Biol"xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/pages | "1042-1056"xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/title | "Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan."xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/23669073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23669073 |
| http://purl.uniprot.org/citations/23669073 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23669073 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFR7-mappedCitation-23669073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23669073 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KEW6-mappedCitation-23669073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23669073 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LF47-mappedCitation-23669073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23669073 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFE6-mappedCitation-23669073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23669073 |