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| http://purl.uniprot.org/citations/23676498 | http://www.w3.org/2000/01/rdf-schema#comment | "Abnormalities in cell-cell communication and growth factor signaling pathways can lead to defects in maternal-fetal interactions during pregnancy, including immunologic rejection of the fetal/placental unit. In this study, we discovered that bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation physiology and fertility. Despite normal implantation and early placental/fetal development, deletion of Bmpr2 in the uterine deciduae of mice triggered midgestation abnormalities in decidualization that resulted in abnormal vascular development, trophoblast defects, and a deficiency of uterine natural killer cells. Absence of BMPR2 signaling in the uterine decidua consequently suppressed IL-15, VEGF, angiopoietin, and corin signaling. Disruption of these pathways collectively lead to placental abruption, fetal demise, and female sterility, thereby placing BMPR2 at a central point in the regulation of several physiologic signaling pathways and events at the maternal-fetal interface. Since trophoblast invasion and uterine vascular modification are implicated in normal placentation and fetal growth in humans, our findings suggest that abnormalities in uterine BMPR2-mediated signaling pathways can have catastrophic consequences in women for the maintenance of pregnancy."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci65710"xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "Li Q."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "Matzuk M.M."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "Nagashima T."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "Lydon J.P."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "DeMayo F.J."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/author | "Clementi C."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/pages | "2539-2550"xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/title | "BMPR2 is required for postimplantation uterine function and pregnancy maintenance."xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/23676498 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23676498 |
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