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http://purl.uniprot.org/citations/23677789http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23677789http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23677789http://www.w3.org/2000/01/rdf-schema#comment"Respiratory syncytial virus (RSV) is an important human pathogen. Its nucleocapsid (NC), which comprises the negative sense RNA viral genome coated by the viral nucleoprotein N, is a critical assembly that serves as template for both mRNA synthesis and genome replication. We have previously described the X-ray structure of an NC-like structure: a decameric ring formed of N-RNA that mimics one turn of the helical NC. In the absence of experimental data we had hypothesized that the NC helix would be right-handed, as the N-N contacts in the ring appeared to more easily adapt to that conformation. We now unambiguously show that the RSV NC is a left-handed helix. We further show that the contacts in the ring can be distorted to maintain key N-N-protein interactions in a left-handed helix, and discuss the implications of the resulting atomic model of the helical NC for viral replication and transcription."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.org/dc/terms/identifier"doi:10.1099/vir.0.053025-0"xsd:string
http://purl.uniprot.org/citations/23677789http://purl.org/dc/terms/identifier"doi:10.1099/vir.0.053025-0"xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Bhella D."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Bhella D."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Duquerroy S."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Duquerroy S."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Rey F.A."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Rey F.A."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Bakker S.E."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Bakker S.E."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Eleouet J.F."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Eleouet J.F."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Galloux M."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Galloux M."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Conner E."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Conner E."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Loney C."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/author"Loney C."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/name"J. Gen. Virol."xsd:string
http://purl.uniprot.org/citations/23677789http://purl.uniprot.org/core/name"J. Gen. Virol."xsd:string