| http://purl.uniprot.org/citations/23678982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23678982 | http://www.w3.org/2000/01/rdf-schema#comment | "Muscarinic acetylcholine receptors (mAChRs) are well known to transmit extracellular cholinergic signals into the cytoplasm from their position on the cell surface. However, we show here that M1-mAChRs are also highly expressed on intracellular membranes in neurons of the telencephalon and activate signaling cascades distinct from those of cell surface receptors, contributing uniquely to synaptic plasticity. Radioligand-binding experiments with cell-permeable and -impermeable ligands and immunohistochemical observations revealed intracellular and surface distributions of M1-mAChRs in the hippocampus and cortex of rats, mice, and humans, in contrast to the selective occurrence on the cell surface in other tissues. All intracellular muscarinic-binding sites were abolished in M1-mAChR-gene-knockout mice. Activation of cell surface M1-mAChRs in rat hippocampal neurons evoked phosphatidylinositol hydrolysis and network oscillations at theta rhythm, and transiently enhanced long-term potentiation. On the other hand, activation of intracellular M1-mAChRs phosphorylated extracellular-regulated kinase 1/2 and gradually enhanced long-term potentiation. Our data thus demonstrate that M1-mAChRs function at both surface and intracellular sites in telencephalon neurons including the hippocampus, suggesting a new mode of cholinergic transmission in the central nervous system."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.org/dc/terms/identifier | "doi:10.1111/jnc.12306"xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Takahashi N."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Nishio M."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Muramatsu I."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Momiyama T."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Masuoka T."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Uwada J."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Ikegaya Y."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Yonekura Y."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Matsuki N."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Fujibayashi Y."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Anisuzzaman A.S."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/author | "Yoshiki H."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/pages | "360-371"xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/title | "Novel contribution of cell surface and intracellular M1-muscarinic acetylcholine receptors to synaptic plasticity in hippocampus."xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/23678982 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23678982 |
| http://purl.uniprot.org/citations/23678982 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23678982 |
| http://purl.uniprot.org/uniprot/#_P11229-mappedCitation-23678982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23678982 |
| http://purl.uniprot.org/uniprot/#_A6HZR8-mappedCitation-23678982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23678982 |
| http://purl.uniprot.org/uniprot/#_Q53XZ3-mappedCitation-23678982 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23678982 |