| http://purl.uniprot.org/citations/23680781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23680781 | http://www.w3.org/2000/01/rdf-schema#comment | "Bile acids play multiple roles in the physiology of vertebrates; they facilitate lipid absorption, serve as signaling molecules to control carbohydrate and lipid metabolism, and provide a disposal route for cholesterol. Unexpectedly, the α-methylacyl-CoA racemase (Amacr) deficient mice, which are unable to complete the peroxisomal cleavage of C27-precursors to the mature C24-bile acids, are physiologically asymptomatic when maintained on a standard laboratory diet. The aim of this study was to uncover the underlying adaptive mechanism with special reference to cholesterol and bile acid metabolism that allows these mice to have a normal life span. Intestinal cholesterol absorption in Amacr-/-mice is decreased resulting in a 2-fold increase in daily cholesterol excretion. Also fecal excretion of bile acids (mainly C27-sterols) is enhanced 3-fold. However, the body cholesterol pool remains unchanged, although Amacr-deficiency accelerates hepatic sterol synthesis 5-fold. Changes in lipoprotein profiles are mainly due to decreased phospholipid transfer protein activity. Thus Amacr-deficient mice provide a unique example of metabolic regulation, which allows them to have a normal lifespan in spite of the disruption of a major metabolic pathway. This metabolic adjustment can be mainly explained by setting cholesterol and bile acid metabolism to a new balanced level in the Amacr-deficient mouse."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbalip.2013.05.002"xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Hiltunen J.K."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Conzelmann E."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Kotti T.J."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Schmitz W."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Alexson S.E."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Kvist A.P."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Jauhiainen M."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Autio K.J."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Salonurmi T."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Savolainen M.J."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Pirila P.L."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Kuusisto S.M."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/author | "Selkala E.M."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/pages | "1335-1343"xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/title | "Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids."xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://purl.uniprot.org/core/volume | "1831"xsd:string |
| http://purl.uniprot.org/citations/23680781 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23680781 |
| http://purl.uniprot.org/citations/23680781 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23680781 |
| http://purl.uniprot.org/uniprot/#_O09174-mappedCitation-23680781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23680781 |
| http://purl.uniprot.org/uniprot/#_Q3TUS8-mappedCitation-23680781 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23680781 |