| http://purl.uniprot.org/citations/23682316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23682316 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23682316 | http://www.w3.org/2000/01/rdf-schema#comment | "Splenic dendritic cells (DCs) present blood-borne antigens to lymphocytes to promote T cell and antibody responses. The cues involved in positioning DCs in areas of antigen exposure in the spleen are undefined. Here we show that CD4(+) DCs highly express EBI2 and migrate to its oxysterol ligand, 7α,25-OHC. In mice lacking EBI2 or the enzymes needed for generating normal distributions of 7α,25-OHC, CD4(+) DCs are reduced in frequency and the remaining cells fail to situate in marginal zone bridging channels. The CD4(+) DC deficiency can be rescued by LTβR agonism. EBI2-mediated positioning in bridging channels promotes DC encounter with blood-borne particulate antigen. Upon exposure to antigen, CD4(+) DCs move rapidly to the T-B zone interface and promote induction of helper T cell and antibody responses. These findings establish an essential role for EBI2 in CD4(+) DC positioning and homeostasis and in facilitating capture and presentation of blood-borne particulate antigens. DOI:http://dx.doi.org/10.7554/eLife.00757.001."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.00757"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.00757"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/author | "Yi T."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/author | "Yi T."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/pages | "E00757"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/pages | "E00757"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/title | "EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/title | "EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture."xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/23682316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23682316 |
| http://purl.uniprot.org/citations/23682316 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23682316 |
| http://purl.uniprot.org/citations/23682316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23682316 |
| http://purl.uniprot.org/citations/23682316 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23682316 |
| http://purl.uniprot.org/uniprot/Q3U6B2 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/23682316 |
| http://purl.uniprot.org/uniprot/Q3U6B2#attribution-32F945957FB3FC4F27BAE88C602EB506 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23682316 |