| http://purl.uniprot.org/citations/23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23684622 | http://www.w3.org/2000/01/rdf-schema#comment | "A major challenge of the post-genomics era is to define the connectivity of protein phosphorylation networks. Here, we quantitatively delineate the insulin signaling network in adipocytes by high-resolution mass spectrometry-based proteomics. These data reveal the complexity of intracellular protein phosphorylation. We identified 37,248 phosphorylation sites on 5,705 proteins in this single-cell type, with approximately 15% responding to insulin. We integrated these large-scale phosphoproteomics data using a machine learning approach to predict physiological substrates of several diverse insulin-regulated kinases. This led to the identification of an Akt substrate, SIN1, a core component of the mTORC2 complex. The phosphorylation of SIN1 by Akt was found to regulate mTORC2 activity in response to growth factors, revealing topological insights into the Akt/mTOR signaling network. The dynamic phosphoproteome described here contains numerous phosphorylation sites on proteins involved in diverse molecular functions and should serve as a useful functional resource for cell biologists."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2013.04.010"xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "James D.E."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Humphrey S.J."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Yang J.Y."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Stockli J."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/author | "Fazakerley D.J."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/pages | "1009-1020"xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/title | "Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2."xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/23684622 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23684622 |
| http://purl.uniprot.org/citations/23684622 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23684622 |
| http://purl.uniprot.org/uniprot/#_A4FUQ9-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_Q15286-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_P24386-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_P50395-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_Q925G8-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_P26374-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_P31749-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |
| http://purl.uniprot.org/uniprot/#_P31150-mappedCitation-23684622 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684622 |