| http://purl.uniprot.org/citations/23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23684985 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms underlying the silencing of alternative fate potentials in very early B cell precursors remain unclear. Using gain- and loss-of-function approaches together with a synthetic Zinc-finger polypeptide (6ZFP) engineered to prevent transcription factor binding to a defined cis element, we show that the transcription factor EBF1 promotes B cell lineage commitment by directly repressing expression of the T-cell-lineage-requisite Gata3 gene. Ebf1-deficient lymphoid progenitors exhibited increased T cell lineage potential and elevated Gata3 transcript expression, whereas enforced EBF1 expression inhibited T cell differentiation and caused rapid loss of Gata3 mRNA. Notably, 6ZFP-mediated perturbation of EBF1 binding to a Gata3 regulatory region restored Gata3 expression, abrogated EBF1-driven suppression of T cell differentiation, and prevented B cell differentiation via a GATA3-dependent mechanism. Furthermore, EBF1 binding to Gata3 regulatory sites induced repressive histone modifications across this region. These data identify a transcriptional circuit critical for B cell lineage commitment."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2013.01.014"xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/author | "Banerjee A."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/author | "Jacobsen S.E."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/author | "Allman D."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/author | "Boukarabila H."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/author | "Northrup D."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/pages | "930-942"xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/title | "Transcriptional repression of Gata3 is essential for early B cell commitment."xsd:string |
| http://purl.uniprot.org/citations/23684985 | http://purl.uniprot.org/core/volume | "38"xsd:string |
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| http://purl.uniprot.org/citations/23684985 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23684985 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVX2-mappedCitation-23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684985 |
| http://purl.uniprot.org/uniprot/#_A0A087WST9-mappedCitation-23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684985 |
| http://purl.uniprot.org/uniprot/#_Q07802-mappedCitation-23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684985 |
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| http://purl.uniprot.org/uniprot/#_A2AKM5-mappedCitation-23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684985 |
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| http://purl.uniprot.org/uniprot/#_A0A3Q4EHG2-mappedCitation-23684985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23684985 |