| http://purl.uniprot.org/citations/23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23685072 | http://www.w3.org/2000/01/rdf-schema#comment | "Oncogene-induced senescence is an important tumor-suppressing defense mechanism. However, relatively little is known about the signaling pathway mediating the senescence response. Here, we demonstrate that a multifunctional acetyltransferase, Tip60, plays an essential role in oncogenic ras-induced senescence. Further investigation reveals a cascade of posttranslational modifications involving p38, Tip60, and PRAK, three proteins that are essential for ras-induced senescence. Upon activation by ras, p38 induces the acetyltransferase activity of Tip60 through phosphorylation of Thr158; activated Tip60 in turn directly interacts with and induces the protein kinase activity of PRAK through acetylation of K364 in a manner that depends on phosphorylation of both Tip60 and PRAK by p38. These posttranslational modifications are critical for the prosenescent function of Tip60 and PRAK, respectively. These results have defined a signaling pathway that mediates oncogene-induced senescence, and identified posttranslational modifications that regulate the enzymatic activity and biological functions of Tip60 and PRAK."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.04.013"xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Han X."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Liao R."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Sun P."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Yates J.R."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Aslanian A."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Seit-Nebi A."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/author | "Tat J."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/pages | "699-710"xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/title | "A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence."xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/23685072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23685072 |
| http://purl.uniprot.org/citations/23685072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23685072 |
| http://purl.uniprot.org/uniprot/#_A0A510GDE6-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_B2R8A7-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_B4E0K5-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_B5TY33-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_Q15454-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_L7RSM2-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |
| http://purl.uniprot.org/uniprot/#_Q16539-mappedCitation-23685072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685072 |