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http://purl.uniprot.org/citations/23685212http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23685212http://www.w3.org/2000/01/rdf-schema#comment"Human APOBEC3F is an antiretroviral single-strand DNA cytosine deaminase, susceptible to degradation by the HIV-1 protein Vif. In this study the crystal structure of the HIV Vif binding, catalytically active, C-terminal domain of APOBEC3F (A3F-CTD) was determined. The A3F-CTD shares structural motifs with portions of APOBEC3G-CTD, APOBEC3C, and APOBEC2. Residues identified to be critical for Vif-dependent degradation of APOBEC3F all fit within a predominantly negatively charged contiguous region on the surface of A3F-CTD. Specific sequence motifs, previously shown to play a role in Vif susceptibility and virion encapsidation, are conserved across APOBEC3s and between APOBEC3s and HIV-1 Vif. In this structure these motifs pack against each other at intermolecular interfaces, providing potential insights both into APOBEC3 oligomerization and Vif interactions."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.org/dc/terms/identifier"doi:10.1016/j.str.2013.04.010"xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Anderson B.D."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Lu Y."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Matsuo H."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Albin J.S."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Bohn M.F."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Carpenter M.A."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Harris R.S."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Rathore A."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Schiffer C.A."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Shandilya S.M."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Somasundaran M."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Kouno T."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Evans L."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"McDougle R.M."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/author"Davis A.N."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/name"Structure"xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/pages"1042-1050"xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/title"Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain."xsd:string
http://purl.uniprot.org/citations/23685212http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/23685212http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23685212