| http://purl.uniprot.org/citations/23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23685627 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is the primary cellular catabolic program activated in response to nutrient starvation. Initiation of autophagy, particularly by amino-acid withdrawal, requires the ULK kinases. Despite its pivotal role in autophagy initiation, little is known about the mechanisms by which ULK promotes autophagy. Here we describe a molecular mechanism linking ULK to the pro-autophagic lipid kinase VPS34. Following amino-acid starvation or mTOR inhibition, the activated ULK1 phosphorylates Beclin-1 on Ser 14, thereby enhancing the activity of the ATG14L-containing VPS34 complexes. The Beclin-1 Ser 14 phosphorylation by ULK is required for full autophagic induction in mammals and this requirement is conserved in Caenorhabditis elegans. Our study reveals a molecular link from ULK1 to activation of the autophagy-specific VPS34 complex and autophagy induction."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2757"xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Tian Y."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Chang Y.Y."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Dillin A."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Russell R.C."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Neufeld T.P."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/author | "Park H.W."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/pages | "741-750"xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/title | "ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase."xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/23685627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23685627 |
| http://purl.uniprot.org/citations/23685627 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23685627 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JG09-mappedCitation-23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685627 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B3-mappedCitation-23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685627 |
| http://purl.uniprot.org/uniprot/#_E9QAM0-mappedCitation-23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685627 |
| http://purl.uniprot.org/uniprot/#_E0CYU7-mappedCitation-23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685627 |
| http://purl.uniprot.org/uniprot/#_E0CYY6-mappedCitation-23685627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23685627 |