| http://purl.uniprot.org/citations/23687042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23687042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23687042 | http://www.w3.org/2000/01/rdf-schema#comment | "In Gram-negative bacteria, outer-membrane integrity is essential for survival and is monitored by the σ(E) stress-response system, which initiates damage-repair pathways. One activating signal is unassembled outer-membrane proteins. Using biochemical and genetic experiments in Escherichia coli, we found that off-pathway intermediates in lipopolysaccharide transport and assembly provided an additional required signal. These distinct signals, arising from disruptions in the transport and assembly of the major outer-membrane components, jointly determined the rate of proteolytic destruction of a negative regulator of the σ(E) transcription factor, thereby modulating the expression of stress-response genes. This dual-signal system permits a rapid response to dysfunction in outer-membrane biogenesis, while buffering responses to transient fluctuations in individual components, and may represent a broad strategy for bacteria to monitor their interface with the environment."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1235358"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1235358"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Gross C.A."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Gross C.A."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Sauer R.T."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Sauer R.T."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Chaba R."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Chaba R."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Guo M.S."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Guo M.S."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Lima S."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/author | "Lima S."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/pages | "837-841"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/pages | "837-841"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/title | "Dual molecular signals mediate the bacterial response to outer-membrane stress."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/title | "Dual molecular signals mediate the bacterial response to outer-membrane stress."xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/23687042 | http://purl.uniprot.org/core/volume | "340"xsd:string |