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| http://purl.uniprot.org/citations/23687047 | http://www.w3.org/2000/01/rdf-schema#comment | "Evidence for transcriptional feedback in circadian timekeeping is abundant, yet little is known about the mechanisms underlying translational control. We found that ATAXIN-2 (ATX2), an RNA-associated protein involved in neurodegenerative disease, is a translational activator of the rate-limiting clock component PERIOD (PER) in Drosophila. ATX2 specifically interacted with TWENTY-FOUR (TYF), an activator of PER translation. RNA interference-mediated depletion of Atx2 or the expression of a mutant ATX2 protein that does not associate with polyadenylate-binding protein (PABP) suppressed behavioral rhythms and decreased abundance of PER. Although ATX2 can repress translation, depletion of Atx2 from Drosophila S2 cells inhibited translational activation by RNA-tethered TYF and disrupted the association between TYF and PABP. Thus, ATX2 coordinates an active translation complex important for PER expression and circadian rhythms."xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1234785"xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/author | "Lim C."xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/author | "Allada R."xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/pages | "875-879"xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/title | "ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/23687047 | http://purl.uniprot.org/core/volume | "340"xsd:string |
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