| http://purl.uniprot.org/citations/23690138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23690138 | http://www.w3.org/2000/01/rdf-schema#comment | "Neural tube defects (NTDs) are serious congenital malformation of fusion failure of the neural tube during early embryogenesis. DNA methylation disorders have been found in NTD-affected fetuses, and are correlated to the risk of NTDs. The insulin-like growth factor 2 (IGF2) gene, maternally imprinted, has a key role in fetal development. IGF2 transcription is partly controlled by differentially methylated regions (DMRs) 0 and 2. To assess whether disturbed methylation pattern increases the incidence of NTDs, we employed matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to quantify CpG methylation levels of DMR2 and 0 in fetuses with or without NTDs. We found that the methylation level of IGF2 DMR0 increased significantly in the brain tissues of NTD-affected fetuses. And hypermethylation of DMR0 was associated with an increased risk of NTDs, with an odds ratio of 5.375 (95 % CI: 1.447-19.965; p = 0.007). IGF2 mRNA expression was negatively correlated with the methylation level of DMR0 (R (2) = 0.893; p = 0.000) in HCT15 cells. These results highlights that IGF2 DMR0 hypermethylation is a potential risk factor of NTD, and IGF2 gene is a promising candidate gene to study for a greater understanding of the cause of NTDs."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-013-1655-1"xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Chang S."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Guo J."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Lu X."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Guo J.'"xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Wang F."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Niu B."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/author | "Shangguan S."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/pages | "33-42"xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/title | "Altered methylation of IGF2 DMR0 is associated with neural tube defects."xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://purl.uniprot.org/core/volume | "380"xsd:string |
| http://purl.uniprot.org/citations/23690138 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23690138 |
| http://purl.uniprot.org/citations/23690138 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23690138 |
| http://purl.uniprot.org/uniprot/#_B2MUX6-mappedCitation-23690138 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23690138 |