| http://purl.uniprot.org/citations/23690469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23690469 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23690469 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we identify transmembrane protein 131-like (TMEM131L) as a novel regulator of thymocyte proliferation and demonstrate that it corresponds to a not as yet reported inhibitor of Wnt signaling. Short hairpin RNA-mediated silencing of TMEM131L in human CD34(+) hematopoietic progenitors, which were then grafted in NOD-SCID/IL-2rγ(null) mice, resulted in both thymocyte hyperproliferation and multiple pre- and post-β-selection intrathymic developmental defects. Consistent with deregulated Wnt signaling, TMEM131L-deficient thymocytes expressed Wnt target genes at abnormally high levels, and they displayed both constitutive phosphorylation of Wnt coreceptor LRP6 and β-catenin intranuclear accumulation. Using T cell factor reporter assays, we found that membrane-associated TMEM131L inhibited canonical Wnt/β-catenin signaling at the LRP6 coreceptor level. Whereas membrane-associated TMEM131L did not affect LRP6 expression under basal conditions, it triggered lysosome-dependent degradation of its active phosphorylated form following Wnt activation. Genetic mapping showed that phosphorylated LRP6 degradation did not depend on TMEM131L cytoplasmic part but rather on a conserved extracellular domain proximal to the membrane. Collectively, these data indicate that, during thymopoiesis, stage-specific surface translocation of TMEM131L may regulate immature single-positive thymocyte proliferation arrest by acting through mixed Wnt-dependent and -independent mechanisms."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300400"xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300400"xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Canque B."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Canque B."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Gluckman J.C."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Gluckman J.C."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Maharzi N."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Maharzi N."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Nelson E."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Nelson E."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Parcelier A."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Parcelier A."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Parietti V."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Parietti V."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Pla M."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Pla M."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Robledo-Sarmiento M."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Robledo-Sarmiento M."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Sigaux F."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Sigaux F."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Setterblad N."xsd:string |
| http://purl.uniprot.org/citations/23690469 | http://purl.uniprot.org/core/author | "Setterblad N."xsd:string |