| http://purl.uniprot.org/citations/23695162 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23695162 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen induces signal transduction through estrogen receptor α (ERα), which localizes to both the plasma membrane and nucleus. Using wild-type mice, ERα knockout (ERKO) mice, or transgenic mice expressing only the ligand-binding domain of ERα exclusively at the plasma membrane (MOER), we compared the transcriptional profiles of liver tissue extracts after mice were injected with the ERα agonist propyl-pyrazole-triol (PPT). The expression of many lipid synthesis-related genes was comparably decreased in livers from MOER or wild-type mice but was not suppressed in ERKO mice, indicating that only membrane-localized ERα was necessary for their suppression. Cholesterol, triglyceride, and fatty acid content was decreased only in livers from wild-type and MOER mice exposed to PPT, but not in the livers from the ERKO mice, validating the membrane-driven signaling pathway on a physiological level. PPT-triggered activation of ERα at the membrane induced adenosine monophosphate-activated protein kinase to phosphorylate sterol regulatory element-binding factor 1 (Srebf1), preventing its association with and therefore its proteolytic cleavage by site-1 protease. Consequently, Srebf1 was sequestered in the cytoplasm, preventing the expression of cholesterol synthesis-associated genes. Thus, we showed that inhibition of gene expression mediated by membrane-localized ERα caused a metabolic phenotype that did not require nuclear ERα."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2004013"xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "Harvey B.J."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "Levin E.R."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "Pedram A."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "Razandi M."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "O'Mahony F."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/author | "Harvey H."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/pages | "ra36"xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/title | "Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/23695162 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23695162 |
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