| http://purl.uniprot.org/citations/23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23695700 | http://www.w3.org/2000/01/rdf-schema#comment | "Emphysema is one of the disease conditions that comprise chronic obstructive pulmonary disease. Prothymosin α transgenic mice exhibit an emphysema phenotype, but the pathophysiological role of prothymosin α in emphysema remains unclear. Here we show that prothymosin α contributes to the pathogenesis of emphysema by increasing acetylation of histones and nuclear factor-kappaB, particularly upon cigarette smoke exposure. We find a positive correlation between prothymosin α levels and the severity of emphysema in prothymosin α transgenic mice and emphysema patients. Prothymosin α overexpression increases susceptibility to cigarette smoke-induced emphysema, and cigarette smoke exposure further enhances prothymosin α expression. We show that prothymosin α inhibits the association of histone deacetylases with histones and nuclear factor-kappaB, and that prothymosin α overexpression increases expression of nuclear factor-kappaB-dependent matrix metalloproteinase 2 and matrix metalloproteinase 9, which are found in the lungs of patients with chronic obstructive pulmonary disease. These results demonstrate the clinical relevance of prothymosin α in regulating acetylation events during the pathogenesis of emphysema."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2906"xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Chen Y.C."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Li K.J."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Wu P."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Wu C.L."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Tseng Y.L."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Shiau A.L."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Su B.H."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Yen T.H."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Shieh G.S."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/author | "Shiang Y.C."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/pages | "1906"xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/title | "Prothymosin alpha overexpression contributes to the development of pulmonary emphysema."xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/23695700 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23695700 |
| http://purl.uniprot.org/citations/23695700 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23695700 |
| http://purl.uniprot.org/uniprot/#_A0A087WPN6-mappedCitation-23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23695700 |
| http://purl.uniprot.org/uniprot/#_A0A087WQN2-mappedCitation-23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23695700 |
| http://purl.uniprot.org/uniprot/#_A0A087WP98-mappedCitation-23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23695700 |
| http://purl.uniprot.org/uniprot/#_P26350-mappedCitation-23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23695700 |
| http://purl.uniprot.org/uniprot/#_Q53S24-mappedCitation-23695700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23695700 |