| http://purl.uniprot.org/citations/23703573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23703573 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a crucial regulator in GLP-1-induced insulin gene expression and insulin secretion via upregulation of pancreatic duodenal homeobox-1 (PDX-1) in pancreatic β-cells. GLP-1 treatment significantly increased BTG2, PDX-1 and insulin gene expression in pancreatic β-cells. Notably, adenovirus-mediated overexpression of BTG2 significantly elevated insulin secretion, as well as insulin and PDX-1 gene expression. Physical interaction studies showed that BTG2 is associated with increased PDX-1 occupancy on the insulin gene promoter via a direct interaction with PDX-1. Exendin-4 (Ex-4), a GLP-1 agonist, and GLP-1 in pancreatic β-cells increased insulin secretion through the BTG2-PDX-1-insulin pathway, which was blocked by endogenous BTG2 knockdown using a BTG2 small interfering RNA knockdown system. Finally, we revealed that Ex-4 and GLP-1 significantly elevated insulin secretion via upregulation of the BTG2-PDX-1 axis in pancreatic islets, and this phenomenon was abolished by endogenous BTG2 knockdown. Collectively, our current study provides a novel molecular mechanism by which GLP-1 positively regulates insulin gene expression via BTG2, suggesting that BTG2 has a key function in insulin secretion in pancreatic β-cells."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.org/dc/terms/identifier | "doi:10.1038/emm.2013.47"xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/author | "Lee I.K."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/author | "Kim S.G."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/author | "Kwon O."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/author | "Kim Y.D."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/author | "Hwang S.L."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/name | "Exp Mol Med"xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/pages | "e25"xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/title | "B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic beta-cells."xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/23703573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23703573 |
| http://purl.uniprot.org/citations/23703573 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23703573 |
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| http://purl.uniprot.org/uniprot/#_P52947-mappedCitation-23703573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23703573 |
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