| http://purl.uniprot.org/citations/23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23704370 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ski2-like RNA helicase Brr2 is a core component of the spliceosome that must be tightly regulated to ensure correct timing of spliceosome activation. Little is known about mechanisms of regulation of Ski2-like helicases by protein cofactors. Here we show by crystal structure and biochemical analyses that the Prp8 protein, a major regulator of the spliceosome, can insert its C-terminal tail into Brr2's RNA-binding tunnel, thereby intermittently blocking Brr2's RNA-binding, adenosine triphosphatase, and U4/U6 unwinding activities. Inefficient Brr2 repression is the only recognizable phenotype associated with certain retinitis pigmentosa-linked Prp8 mutations that map to its C-terminal tail. Our data show how a Ski2-like RNA helicase can be reversibly inhibited by a protein cofactor that directly competes with RNA substrate binding."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1237515"xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Luhrmann R."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Santos K.F."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Will C.L."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Mozaffari-Jovin S."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/author | "Wandersleben T."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/pages | "80-84"xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/title | "Inhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8."xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://purl.uniprot.org/core/volume | "341"xsd:string |
| http://purl.uniprot.org/citations/23704370 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23704370 |
| http://purl.uniprot.org/citations/23704370 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23704370 |
| http://purl.uniprot.org/uniprot/#_A4FU77-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_A2RRQ7-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_B4DK16-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_B4E150-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_B4E0P5-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_Q53GM6-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_O75643-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_P32639-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |
| http://purl.uniprot.org/uniprot/#_P33334-mappedCitation-23704370 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704370 |