| http://purl.uniprot.org/citations/23704570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23704570 | http://www.w3.org/2000/01/rdf-schema#comment | "Itch is triggered by somatosensory neurons expressing the ion channel TRPV1 (transient receptor potential cation channel subfamily V member 1), but the mechanisms underlying this nociceptive response remain poorly understood. Here, we show that the neuropeptide natriuretic polypeptide b (Nppb) is expressed in a subset of TRPV1 neurons and found that Nppb(-/-) mice selectively lose almost all behavioral responses to itch-inducing agents. Nppb triggered potent scratching when injected intrathecally in wild-type and Nppb(-/-) mice, showing that this neuropeptide evokes itch when released from somatosensory neurons. Itch responses were blocked by toxin-mediated ablation of Nppb-receptor-expressing cells, but a second neuropeptide, gastrin-releasing peptide, still induced strong responses in the toxin-treated animals. Thus, our results define the primary pruriceptive neurons, characterize Nppb as an itch-selective neuropeptide, and reveal the next two stages of this dedicated neuronal pathway."xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1233765"xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/author | "Mishra S.K."xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/author | "Hoon M.A."xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/pages | "968-971"xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/title | "The cells and circuitry for itch responses in mice."xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://purl.uniprot.org/core/volume | "340"xsd:string |
| http://purl.uniprot.org/citations/23704570 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23704570 |
| http://purl.uniprot.org/citations/23704570 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23704570 |
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| http://purl.uniprot.org/uniprot/#_Q794A8-mappedCitation-23704570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704570 |
| http://purl.uniprot.org/uniprot/#_P40753-mappedCitation-23704570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704570 |
| http://purl.uniprot.org/uniprot/#_Q54AE9-mappedCitation-23704570 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704570 |
| http://purl.uniprot.org/uniprot/P40753 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23704570 |
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