| http://purl.uniprot.org/citations/23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23704922 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-26 (IL-26) is one of the cytokines secreted by Th17 cells whose role in human tumors remains unknown. Here, we investigated the expression and potential role of IL-26 in human gastric cancer (GC). The expression of IL-26 and related molecules such as IL-20R1, STAT1 and STAT3 was examined by real-time PCR and immunohistochemisty. The effects of IL-26 on cell proliferation and cisplatin-induced apoptosis were analyzed by BrdU cooperation assay and PI-Annexin V co-staining, respectively. Lentiviral mediated siRNA was used to explore its mechanism of action, and IL-26 related signaling was analyzed by western blotting. Human GC tissues showed increased levels of IL-26 and its related molecules and activation of STAT3 signaling, whereas STAT1 activation did not differ significantly between GC and normal gastric tissues. Moreover, IL-26 was primarily produced by Th17 and NK cells. IL-26 promoted the proliferation and survival of MKN45 and SGC-7901 gastric cancer cells in a dose-dependent manner. Furthermore, IL-20R2 and IL-10R1, which are two essential receptors for IL-26 signaling, were expressed in both cell lines. IL-26 activated STAT1 and STAT3 signaling; however, the upregulation of the expression of Bcl-2, Bcl-xl and c-myc indicated that the effect of IL-26 is mediated by STAT3 activation. Knockdown of STAT1 and STAT3 expression suggested that the proliferative and anti-apoptotic effects of IL-26 are mediated by the modulation of STAT1/STAT3 activation. In summary, elevated levels of IL-26 in human GC promote proliferation and survival by modulating STAT1/STAT3 signaling."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0063588"xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Gu C."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "Tang Q."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/author | "You W."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/pages | "e63588"xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/title | "IL-26 promotes the proliferation and survival of human gastric cancer cells by regulating the balance of STAT1 and STAT3 activation."xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23704922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23704922 |
| http://purl.uniprot.org/citations/23704922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23704922 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_Q08334-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_Q9NPH9-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_P29597-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_P23458-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_P40763-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/#_Q9UHF4-mappedCitation-23704922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23704922 |
| http://purl.uniprot.org/uniprot/P29597 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23704922 |