| http://purl.uniprot.org/citations/23706739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23706739 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23706739 | http://www.w3.org/2000/01/rdf-schema#comment | "Histone acetylation plays critical roles in chromatin remodeling, DNA repair, and epigenetic regulation of gene expression, but the underlying mechanisms are unclear. Proteasomes usually catalyze ATP- and polyubiquitin-dependent proteolysis. Here, we show that the proteasomes containing the activator PA200 catalyze the polyubiquitin-independent degradation of histones. Most proteasomes in mammalian testes ("spermatoproteasomes") contain a spermatid/sperm-specific α subunit α4 s/PSMA8 and/or the catalytic β subunits of immunoproteasomes in addition to PA200. Deletion of PA200 in mice abolishes acetylation-dependent degradation of somatic core histones during DNA double-strand breaks and delays core histone disappearance in elongated spermatids. Purified PA200 greatly promotes ATP-independent proteasomal degradation of the acetylated core histones, but not polyubiquitinated proteins. Furthermore, acetylation on histones is required for their binding to the bromodomain-like regions in PA200 and its yeast ortholog, Blm10. Thus, PA200/Blm10 specifically targets the core histones for acetylation-mediated degradation by proteasomes, providing mechanisms by which acetylation regulates histone degradation, DNA repair, and spermatogenesis."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.032"xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.04.032"xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Cheng Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Goldberg A.L."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Goldberg A.L."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Komatsu T."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Komatsu T."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Pang Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Pang Y."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/23706739 | http://purl.uniprot.org/core/author | "Song W."xsd:string |